At which primary receptor does DMT act as a full agonist to produce its psychedelic effects?

The 5-HT2A receptor is a subtype of serotonin (5-hydroxytryptamine) receptor found abundantly in the brain’s cortex.DMT acts as a partial agonist at this receptor. When it binds and activates 5-HT2A receptors (especially on cortical pyramidal neurons), it disrupts normal sensory processing and network dynamics. This interaction is widely regarded as the primary mechanism underlying DMT’s intense psychedelic effects, similar to how classic psychedelics such as LSD and psilocybin also work primarily through 5-HT2A activation.